Amazon Basic CareEsomeprazole Magnesium Delayed Release Capsules, 20 mg, Acid Reducer, Heartburn Medicine, 42 Count

Good product works well- long term use has side effects so use with physician help. I’ve been using for several years without problems. Best gerd product in my opinion. JWS, RPh!

Same product as name brand for less cost., so a great value for less money.

Works great! No more heart burn.

Amazon product good value for the money compared to brand-name or other products that may be out there. I find this works better than some other generic or stored items as I’ve tried different products of Amazon before. I would stick with the Amazon product.

As good as the name brand and cheaper. Good quality & easy to swallow.

SOURCE :This is an FDA's approved, proton-pump inhibitor [PPI] that Amazon packages and labels. The phone number for the "Question or comments" printed on the box (see my figure A) shows that Amazon's source is L. Perrigo, a Michigan pharmaceutical company legally headquartered in Ireland for tax purposes, which owns a number of subsidiaries around the world, including Agis Industries in Israel, where this generic OTC drug is likely manufactured.INGREDIENTS :[1] The active ingredient is a magnesium salt in dihydrate form of esomeprazole, the chiral s-isomer of the older PPI omeprazole. Although these ingredients cannot be differentiated analytically (but for their chirality), their clinical effects are not identical -- a number of studies have shown that esomeprazole provides better control of intragastric pH and is more effective in treating GERD's esophagitis than omeprazole.[2] Three of the excipients listed on the box (see my figure A) are worth of comment. One is gelatin, used for the capsules, whose origin is unspecified; those with vegetarian or vegan affinities should be aware that, quite more often than not, unspecified gelatin derives from animal tissues (cattle, pork, chicken) rather than cellulose.[3] Another is titanium dioxide, whose dust is deemed a hazardous material by OSHA, and was classified as a "possible carcinogenic" in 2006 by the International Agency for Research on Cancer due to its common use in the form of nanoparticles. Furthermore, the European Food Safety Authority no longer considers titanium dioxide safe as a food additive as of June 2021.[4] The third are the artificial food colorants [AFC] blue#1 and red#3. Adults with ADHD taking this drug ought to be aware that the controversial claims of food dyes posing a hyperactivity risk are not without scientific support, at least regarding small but non-trivial harmful effects on children’s behavior. An example of that is the 2007 Southampton study of McCann and others, a UK clinical trial [reg. no. ISRCTN4481308] that led the European Parliament in 2008 to ask manufacturers to remove several dyes from foods and beverages, or to put on the label the warning "may have an adverse effect on activity and attention in children." This contrasts with the latter, 8-to-6 vote, FDA's decision against such a warning in a 2011 hearing. On April 2021, the California's Office of Environmental Health Hazards Assessment issued a peer-reviewed report concluding that AFCs are associated with adverse neurobehavioral outcomes in children. Adding food dyes to prettify small gelatin capsules for adults is a daft absurdity.RISKS :Taking this PPI at a prescription dose level (e.g., 40 mg), or when it is continued well beyond the recommended course of treatment, or both, involves a number of potential health risks, some better known than others. Worth of comment is hypomagnesemia (that is, low magnesium levels in blood), which can be significantly magnified by antihypertensive drugs, particularly thiazide or loop diuretics in combination with beta-blockers, angiotensin receptor blockers, or ACE inhibitors.PACKAGING :The three-bottle box I got is an ode to plastic waste -- each unopened bottle of about 55 cc is 3/4 empty, and putting the capsules of all the bottles into one (see my figure B) leaves it about 2/3 empty. (Meanwhile in France plastics are being phased out, Amazon...)__

Great price and great product

This is a great size. Works as well as brand name product